Flow cytometric analysis of Ramos cells unstained untreated cells as negative control (blue) or stained untreated (red) or treated with pervanadate (green) using PIK3R1/PIK3R3?(phospho Y458/Y199) monoclonal antibody (SureLight 488).
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq