Products

Flow Cytometry

Entrez GeneID

Gene Name

MAPK14

Gene Alias

CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA

Gene Description

mitogen-activated protein kinase 14

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Other Designations

Csaids binding protein|MAP kinase Mxi2|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|p38 MAP kinase|p38 mitogen activated protein kinase|p38alpha Exip|stress-activated protein kinase 2A

Entrez GeneID

Gene Name

MAPK11

Gene Alias

P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta

Gene Description

mitogen-activated protein kinase 11

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq

Other Designations

OTTHUMP00000196655|mitogen-activated protein kinase p38 beta|mitogen-activated protein kinase p38-2|stress-activated protein kinase-2|stress-activated protein kinase-2b

Entrez GeneID

Gene Name

MAPK13

Gene Alias

MGC99536, PRKM13, SAPK4, p38delta

Gene Description

mitogen-activated protein kinase 13

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. [provided by RefSeq

Other Designations

OTTHUMP00000016282|mitogen-activated protein kinase p38 delta|stress-activated protein kinase 4

Entrez GeneID

Gene Name

MAPK12

Gene Alias

ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3

Gene Description

mitogen-activated protein kinase 12

Omim ID

Gene Ontology

Gene Summary

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq

Other Designations

mitogen-activated protein kinase 3|stress-activated protein kinase 3