MAP2K3/MAP2K6 (phospho S189/S207) monoclonal antibody, clone D3 (APC)
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More Files
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Flow Cytometry
Flow cytometric analysis of HEK293T cells K252a treated cells as negative control (blue) or stained and treated with K252a (red) or treated with UV+TPA (green) using MAP2K3/MAP2K6 (phospho S189/S207) monoclonal antibody (APC).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human MAP2K3/MAP2K6.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding S189/S207 of human MAP2K3/MAP2K6.
Host
Rabbit
Reactivity
Human
Form
Liquid
Conjugation
APC
Purification
Protein A/G Purification
Isotype
IgG1k
Recommend Usage
Flow Cytometry (5 uL/106 cells or 0.05 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 2-8°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of HEK293T cells K252a treated cells as negative control (blue) or stained and treated with K252a (red) or treated with UV+TPA (green) using MAP2K3/MAP2K6 (phospho S189/S207) monoclonal antibody (APC). -
Gene Info — MAP2K3
Entrez GeneID
5606Gene Name
MAP2K3
Gene Alias
MAPKK3, MEK3, MKK3, PRKMK3
Gene Description
mitogen-activated protein kinase kinase 3
Omim ID
602315Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq
Other Designations
MAP kinase kinase 3|MAPK/ERK kinase 3|OTTHUMP00000166044|dual specificity mitogen activated protein kinase kinase 3
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Gene Info — MAP2K6
Entrez GeneID
5608Gene Name
MAP2K6
Gene Alias
MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3
Gene Description
mitogen-activated protein kinase kinase 6
Omim ID
601254Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq
Other Designations
protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
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Interactome
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Pathway
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Disease
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