CBL (phospho Y774) monoclonal antibody, clone R3B8 (PE)
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More Files
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Flow Cytometry
Flow cytometric analysis of Daudi cells with CBL (phospho Y774) monoclonal antibody, clone R3B8 (PE) (Cat # MAB18848). Cell only (blue) or untreated (red) or treated with IFNa + IL-4 + pervanadate (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human CBL.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y774 of human CBL.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Conjugation
PE
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Daudi cells with CBL (phospho Y774) monoclonal antibody, clone R3B8 (PE) (Cat # MAB18848). Cell only (blue) or untreated (red) or treated with IFNa + IL-4 + pervanadate (green). -
Gene Info — CBL
Entrez GeneID
867Gene Name
CBL
Gene Alias
C-CBL, CBL2, RNF55
Gene Description
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Omim ID
165360Gene Ontology
HyperlinkGene Summary
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
Other Designations
oncogene CBL2
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Interactome
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Pathway
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Disease
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