BAD (phospho S112) monoclonal antibody, clone B9 (APC)
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More Files
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Flow Cytometry
Flow cytometric analysis of COS7 cells with BAD (phospho S112) monoclonal antibody, clone B9 (APC) (Cat # MAB18807). Unstained and untreated as negative control (blue) or stained untreated (red) or cell treated with TPA + Calyculin A (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human BAD.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding S112 of human BAD.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Conjugation
APC
Purification
Protein A/G purification
Isotype
IgG1, lamda
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of COS7 cells with BAD (phospho S112) monoclonal antibody, clone B9 (APC) (Cat # MAB18807). Unstained and untreated as negative control (blue) or stained untreated (red) or cell treated with TPA + Calyculin A (green). -
Gene Info — BAD
Entrez GeneID
572Gene Name
BAD
Gene Alias
BBC2, BCL2L8
Gene Description
BCL2-associated agonist of cell death
Omim ID
603167Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq
Other Designations
BCL-X/BCL-2 binding protein|BCL2-antagonist of cell death protein|BCL2-binding component 6|BCL2-binding protein
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Interactome
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Pathway
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Disease
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