EIF4EBP1 (phospho T37/T46) monoclonal antibody, clone A5 (APC)
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More Files
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Flow Cytometry
Flow cytometric analysis of Jurkat cells with EIF4EBP1 (phospho T37/T46) monoclonal antibody, clone A5 (APC) (Cat # MAB18767). Unstained and treated with LY294002 as negative control (blue) or stained and treated with LY294002 (red) or with TPA (green)
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human EIF4EBP1.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding T37/T46 of human EIF4EBP1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Conjugation
APC
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Jurkat cells with EIF4EBP1 (phospho T37/T46) monoclonal antibody, clone A5 (APC) (Cat # MAB18767). Unstained and treated with LY294002 as negative control (blue) or stained and treated with LY294002 (red) or with TPA (green) -
Gene Info — EIF4EBP1
Entrez GeneID
1978Gene Name
EIF4EBP1
Gene Alias
4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I
Gene Description
eukaryotic translation initiation factor 4E binding protein 1
Omim ID
602223Gene Ontology
HyperlinkGene Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq
Other Designations
eIF4E-binding protein 1|phosphorylated heat- and acid-stable protein regulated by insulin 1
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Interactome
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