Cleaved PARP1 (D214) monoclonal antibody, clone H8
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of HeLa cell lysate with Cleaved PARP1 (D214) monoclonal antibody, clone H8 (Cat # MAB18754). Lane 1: treated or Lane 2: untreated with staurosporine.
Flow Cytometry
Flow cytometric analysis of SK-N-MC cells with Cleaved PARP1 (D214) monoclonal antibody, clone H8 (Cat # MAB18754). Unstained and untreated cells as negative control (blue) or stained untreated (red) or treated with staurosporine (green).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human PARP1.
Immunogen
A synthetic peptide corresponding to residues surrounding D214 of human PARP1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.1% BSA and 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of HeLa cell lysate with Cleaved PARP1 (D214) monoclonal antibody, clone H8 (Cat # MAB18754). Lane 1: treated or Lane 2: untreated with staurosporine.Flow Cytometry
Flow cytometric analysis of SK-N-MC cells with Cleaved PARP1 (D214) monoclonal antibody, clone H8 (Cat # MAB18754). Unstained and untreated cells as negative control (blue) or stained untreated (red) or treated with staurosporine (green). -
Gene Info — PARP1
Entrez GeneID
142Gene Name
PARP1
Gene Alias
ADPRT, ADPRT1, PARP, PARP-1, PPOL, pADPRT-1
Gene Description
poly (ADP-ribose) polymerase 1
Omim ID
173870Gene Ontology
HyperlinkGene Summary
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq
Other Designations
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)|ADP-ribosyltransferase NAD(+)|OTTHUMP00000035663|poly (ADP-ribose) polymerase family, member 1|poly(ADP-ribose) polymerase|poly(ADP-ribose) synthetase|poly(ADP-ribosyl)transferase
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Interactome
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Pathway
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Disease
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