CYP3A7 monoclonal antibody, clone F19 P2 H2
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis using CYP3A7 monoclonal antibody, clone F19 P2 H2 (Cat # MAB1860) on various recombinant CYP3A7 proteins.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry staining of human prostate cancer tissue using CYP3A7 monoclonal antibody, clone F19 P2 H2 (Cat # MAB1860).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of CYP3A7.
Immunogen
A synthetic peptide corresponding to C-terminus of human CYP3A7.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using CYP3A7 monoclonal antibody, clone F19 P2 H2 (Cat # MAB1860) on various recombinant CYP3A7 proteins.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry staining of human prostate cancer tissue using CYP3A7 monoclonal antibody, clone F19 P2 H2 (Cat # MAB1860).Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP3A7
Entrez GeneID
1551Gene Name
CYP3A7
Gene Alias
CP37, P450-HFLA
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 7
Omim ID
605340Gene Ontology
HyperlinkGene Summary
This gene, CYP3A7, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The enzyme also metabolizes some drugs such as aflatoxin B1. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Transcript variants have been described, but it is not known whether these transcripts are normally produced. [provided by RefSeq
Other Designations
aryl hydrocarbon hydroxylase|cytochrome P450, subfamily IIIA, polypeptide 7|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Kumarakulasingham M, Rooney PH, Dundas SR, Telfer C, Melvin WT, Curran S, Murray GI.
Clinical Cancer Research 2005 May; 11(10):3758.
Application：IHC, Human, Human colorectal cancer.
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Variability of CYP3A7 expression in human fetal liver.
Leeder JS, Gaedigk R, Marcucci KA, Gaedigk A, Vyhlidal CA, Schindel BP, Pearce RE.
The Journal of Pharmacology and Experimental Therapeutics 2005 Aug; 314(2):626.
Application：WB, Human, Human fetal livers.
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Selective suppressions of human CYP3A forms, CYP3A5 and CYP3A7, by troglitazone in HepG2 cells.
Ogino M, Nagata K, Yamazoe Y.
Drug Metabolism and Pharmacokinetics 2002 Jan; 17(1):42.
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Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
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