CCNE1 monoclonal antibody, clone 168
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CCNE1.
Immunogen
Recombinant protein corresponding to full length human CCNE1.
Host
Mouse
Reactivity
Human, Monkey
Form
Liquid
Isotype
IgG2a
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
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Gene Info — CCNE1
Entrez GeneID
898Gene Name
CCNE1
Gene Alias
CCNE
Gene Description
cyclin E1
Omim ID
123837Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq
Other Designations
cyclin Es|cyclin Et
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Interactome
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Pathway
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Disease
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Publication Reference
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Rescue of cyclin D1 deficiency by knockin cyclin E.
Geng Y, Whoriskey W, Park MY, Bronson RT, Medema RH, Li T, Weinberg RA, Sicinski P.
Cell 1999 Jun; 97(6):767.
Application:KA, WB-Ce, WB-Ti, Human, Mouse, Mouse embryo fibroblasts, Mouse tissues.
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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts.
Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G.
Science 1999 Feb; 283(5403):851.
Application:IF, Frog, Xenopus embryonic blastomeres.
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Cyclin E, a potential prognostic marker for breast cancer.
Keyomarsi K, O'Leary N, Molnar G, Lees E, Fingert HJ, Pardee AB.
Cancer Research 1994 Jan; 54(2):380.
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Rescue of cyclin D1 deficiency by knockin cyclin E.
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