CCND2 monoclonal antibody, clone DCS3.1
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CCND2.
Immunogen
Recombinant His fusion protein corresponding to full length human CCND2.
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Isotype
IgG2a
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
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Gene Info — CCND2
Entrez GeneID
894Gene Name
CCND2
Gene Alias
KIAK0002, MGC102758
Gene Description
cyclin D2
Omim ID
123833Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq
Other Designations
G1/S-specific cyclin D2
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Interactome
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Pathway
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Disease
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Publication Reference
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Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer.
Bartkova J, Lukas J, Müller H, Strauss M, Gusterson B, Bartek J.
Cancer Research 1995 Feb; 55(4):949.
Application:Flow Cyt, IF, WB-Ce, Human, Human head and neck cancer cells.
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Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer.
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