CASP7 monoclonal antibody, clone MCH3-5
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis using CASP7 monoclonal antibody, clone MCH3-5 (Cat # MAB1843) on MCF-7 cells treated with thapsigargin for 48 hours which are negative (lane 1) and positive (lane 2) for caspase-3.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant CASP7.
Immunogen
Recombinant protein corresponding to human CASP7.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis using CASP7 monoclonal antibody, clone MCH3-5 (Cat # MAB1843) on MCF-7 cells treated with thapsigargin for 48 hours which are negative (lane 1) and positive (lane 2) for caspase-3. -
Gene Info — CASP7
Entrez GeneID
840Gene Name
CASP7
Gene Alias
CMH-1, ICE-LAP3, MCH3
Gene Description
caspase 7, apoptosis-related cysteine peptidase
Omim ID
601761Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq
Other Designations
ICE-like apoptotic protease 3|Lice2 alpha/beta/gamma|OTTHUMP00000020510|OTTHUMP00000020511|OTTHUMP00000020512|OTTHUMP00000020514|apoptotic protease MCH-3|caspase 7|caspase 7 isoform delta|caspase 7, apoptosis-related cysteine protease
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Interactome
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Pathway
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Disease
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Publication Reference
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The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7.
Behrensdorf HA, van de Craen M, Knies UE, Vandenabeele P, Clauss M.
FEBS Letters 2000 Jan; 466(1):143.
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Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver.
Chandler JM, Cohen GM, MacFarlane M.
The Journal of Biological Chemistry 1998 May; 273(18):10815.
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Caspases: the executioners of apoptosis.
Cohen GM.
The Biochemical Journal 1997 Aug; 326 ( Pt 1):1.
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The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7.
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