MMP9 monoclonal antibody, clone 4A3
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis of MMP9 expression in recombinant human proenzyme MMP9 (lane 1) and activated enzyme (lane 1) with MMP9 monoclonal antibody, clone 4A3 (Cat # MAB1805).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of MMP9.
Immunogen
A synthetic peptide corresponding to N-terminus of human MMP9.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1-5 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of MMP9 expression in recombinant human proenzyme MMP9 (lane 1) and activated enzyme (lane 1) with MMP9 monoclonal antibody, clone 4A3 (Cat # MAB1805).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — MMP9
Entrez GeneID
4318Gene Name
MMP9
Gene Alias
CLG4B, GELB, MMP-9
Gene Description
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Omim ID
120361Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq
Other Designations
92kD type IV collagenase|OTTHUMP00000031674|gelatinase B|macrophage gelatinase|matrix metalloproteinase 9|matrix metalloproteinase 9 (gelatinase B, 92kD gelatinase, 92kD type IV collagenase)|matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kD
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Interactome
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Pathway
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Disease
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Publication Reference
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Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories.
Somiari SB, Somiari RI, Heckman CM, Olsen CH, Jordan RM, Russell SJ, Shriver CD.
International Journal of Cancer 2006 Sep; 119(6):1403.
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Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration.
Wang L, Zhang ZG, Zhang RL, Gregg SR, Hozeska-Solgot A, LeTourneau Y, Wang Y, Chopp M.
Journal of Neuroscience 2006 May; 26(22):5996.
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Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells.
Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A.
International Journal of Cancer 2005 Aug; 116(1):52.
Application：Func, Mouse, Mouse plasma.
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Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories.
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