DDR1 monoclonal antibody, clone 4F2C12
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: DDR1-hIgGFc transfected HEK293 cell lysates with DDR1 monoclonal antibody, clone 4F2C12 (Cat # MAB17982).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with DDR1 monoclonal antibody, clone 4F2C12 (Cat # MAB17982).
Flow Cytometry
Flow cytometric analysis of Ramos cells with DDR1 monoclonal antibody, clone 4F2C12 (Cat # MAB17982) (Green). Red: Negative Control.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human DDR1.
Immunogen
Recombinant protein corresponding to amino acids 21-176 of human DDR1.
Host
Mouse
Theoretical MW (kDa)
101
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: DDR1-hIgGFc transfected HEK293 cell lysates with DDR1 monoclonal antibody, clone 4F2C12 (Cat # MAB17982).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with DDR1 monoclonal antibody, clone 4F2C12 (Cat # MAB17982).Flow Cytometry
Flow cytometric analysis of Ramos cells with DDR1 monoclonal antibody, clone 4F2C12 (Cat # MAB17982) (Green). Red: Negative Control. -
Gene Info — DDR1
Entrez GeneID
780Protein Accession#
Q08345Gene Name
DDR1
Gene Alias
CAK, CD167, DDR, EDDR1, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE
Gene Description
discoidin domain receptor tyrosine kinase 1
Omim ID
600408Gene Ontology
HyperlinkGene Summary
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000029343|OTTHUMP00000029344|OTTHUMP00000029345|OTTHUMP00000029346|OTTHUMP00000029347|PTK3A protein tyrosine kinase 3A|cell adhesion kinase|discoidin domain receptor DDR1d|discoidin domain receptor family, member 1|discoidin receptor tyrosine kin
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Interactome
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Disease
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