SIRPA monoclonal antibody, clone 3C8C12
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: SIRPA-hIgGFc transfected HEK293 cell lysates with SIRPA monoclonal antibody, clone 3C8C12 (Cat # MAB17965).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with SIRPA monoclonal antibody, clone 3C8C12 (Cat # MAB17965).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human SIRPA.
Immunogen
Recombinant protein corresponding to amino acids 235-373 of human SIRPA.
Host
Mouse
Theoretical MW (kDa)
55
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: SIRPA-hIgGFc transfected HEK293 cell lysates with SIRPA monoclonal antibody, clone 3C8C12 (Cat # MAB17965).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with SIRPA monoclonal antibody, clone 3C8C12 (Cat # MAB17965). -
Gene Info — SIRPA
Entrez GeneID
140885Protein Accession#
P78324Gene Name
SIRPA
Gene Alias
BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS-1, SHPS1, SIRP, SIRP-ALPHA-1, SIRPalpha, SIRPalpha2
Gene Description
signal-regulatory protein alpha
Omim ID
602461Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030001|SHP substrate-1|brain-immunoglobulin-like molecule with tyrosine-based activation motifs|macrophage fusion receptor|myd-1 antigen|protein tyrosine phosphatase, non-receptor type substrate 1|signal regulatory protein, alpha type 1|signal
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