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Last updated: 2016/10/23
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NAPA monoclonal antibody, clone 15D4

  • Catalog # : MAB1795
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant NAPA.
  • Immunogen:
  • Recombinant protein corresponding to human NAPA.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 36
  • Reactivity:
  • Human
  • Specificity:
  • This antibody specifically recognizes alpha SNAP as a single band of ~36 KDa on western blot of rat kidney, rat brain and MDBK cells and do not recognize beta SNAP.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western Blot (0.5-5 ug/mL)
    Immunoprecipitation (2-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM sodium phosphate buffer, 150 mM NaCl, pH 7.5 (50% glycerol)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 8775
  • Gene Name:
  • NAPA
  • Gene Alias:
  • Gene Description:
  • N-ethylmaleimide-sensitive factor attachment protein, alpha
  • Gene Summary:
  • The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport. The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively. Platelets contain some of the same proteins, including NSF, p115/TAP, alpha-SNAP, gamma-SNAP, and the t-SNAREs syntaxin-2 and syntaxin-4, that are used in many vesicular transport processes in other cell types. Platelet exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as neurons, although the proteins used by the platelet and their modes of regulation may be quite different. [provided by RefSeq
  • Other Designations:
  • alpha-SNAP
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