BCR monoclonal antibody, clone 6B5E12
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: BCR-hIgGFc transfected HEK293 cell lysates with BCR monoclonal antibody, clone 6B5E12 (Cat # MAB17934).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with BCR monoclonal antibody, clone 6B5E12 (Cat # MAB17934).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human BCR.
Immunogen
Recombinant protein corresponding to amino acids 139-280 of human BCR.
Host
Mouse
Theoretical MW (kDa)
142.8
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: BCR-hIgGFc transfected HEK293 cell lysates with BCR monoclonal antibody, clone 6B5E12 (Cat # MAB17934).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with BCR monoclonal antibody, clone 6B5E12 (Cat # MAB17934). -
Gene Info — BCR
Entrez GeneID
613Protein Accession#
P11274Gene Name
BCR
Gene Alias
ALL, BCR-ABL1, BCR1, CML, D22S11, D22S662, FLJ16453, PHL
Gene Description
breakpoint cluster region
Gene Ontology
HyperlinkGene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
bcr-abl1 e14a3 chimeric protein
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Interactome
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Pathway
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Disease
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