ACVR1 monoclonal antibody, clone 2E2C11
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: ACVR1-hIgGFc transfected HEK293 cell lysates with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ovarian cancer with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926).
Immunofluorescence
Immunofluorescent staining of HeLa cells with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926) (Green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926).
Flow Cytometry
Flow cytometric analysis of HeLa cells with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926) (Green). Red: Negative Control.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ACVR1.
Immunogen
Recombinant protein corresponding to amino acids 21-120 of human ACVR1.
Host
Mouse
Theoretical MW (kDa)
57.2
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Immunofluorescence (1:200-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: ACVR1-hIgGFc transfected HEK293 cell lysates with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ovarian cancer with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926).Immunofluorescence
Immunofluorescent staining of HeLa cells with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926) (Green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.Enzyme-linked Immunoabsorbent Assay
ELISA analysis with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926).Flow Cytometry
Flow cytometric analysis of HeLa cells with ACVR1 monoclonal antibody, clone 2E2C11 (Cat # MAB17926) (Green). Red: Negative Control. -
Gene Info — ACVR1
Entrez GeneID
90Protein Accession#
Q04771Gene Name
ACVR1
Gene Alias
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Gene Description
activin A receptor, type I
Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq
Other Designations
TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 2|activin A type I receptor|hydroxyalkyl-protein kinase|serine/threonine-protein kinase receptor R1
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Interactome
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Pathway
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Disease
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