PRKAA2 monoclonal antibody, clone 5B4G1
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: PRKAA2-hIgGFc transfected HEK293 cell lysates with PRKAA2 monoclonal antibody, clone 5B4G1 (Cat # MAB17898).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human esophagus cancer with PRKAA2 monoclonal antibody, clone 5B4G1 (Cat # MAB17898).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with PRKAA2 monoclonal antibody, clone 5B4G1 (Cat # MAB17898).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human PRKAA2.
Immunogen
Recombinant protein corresponding to amino acids 453-552 of human PRKAA2.
Host
Mouse
Theoretical MW (kDa)
62.3
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: PRKAA2-hIgGFc transfected HEK293 cell lysates with PRKAA2 monoclonal antibody, clone 5B4G1 (Cat # MAB17898).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human esophagus cancer with PRKAA2 monoclonal antibody, clone 5B4G1 (Cat # MAB17898).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with PRKAA2 monoclonal antibody, clone 5B4G1 (Cat # MAB17898). -
Gene Info — PRKAA2
Entrez GeneID
5563Protein Accession#
P54646Gene Name
PRKAA2
Gene Alias
AMPK, AMPK2, PRKAA
Gene Description
protein kinase, AMP-activated, alpha 2 catalytic subunit
Omim ID
600497Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq
Other Designations
5'-AMP-activated protein kinase, catalytic alpha-2 chain|AMP-activated protein kinase alpha 2 catalytic subunit|AMPK-alpha-2 chain|OTTHUMP00000009993
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Interactome
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Pathway
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Disease
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