VAV1 monoclonal antibody, clone 200000000000
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Jurkat cell lysate with VAV1 monoclonal antibody, clone 200000000000 (Cat # MAB17876).
Enzyme-linked Immunoabsorbent Assay
ELISA analysis with VAV1 monoclonal antibody, clone 200000000000 (Cat # MAB17876).
Flow Cytometry
Flow cytometric analysis of HeLa cells with VAV1 monoclonal antibody, clone 200000000000 (Cat # MAB17876) (Green). Red: Negative Control.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human VAV1.
Immunogen
Recombinant protein corresponding to amino acids 121-324 of human VAV1.
Host
Mouse
Theoretical MW (kDa)
98.3
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:100-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Jurkat cell lysate with VAV1 monoclonal antibody, clone 200000000000 (Cat # MAB17876).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with VAV1 monoclonal antibody, clone 200000000000 (Cat # MAB17876).Flow Cytometry
Flow cytometric analysis of HeLa cells with VAV1 monoclonal antibody, clone 200000000000 (Cat # MAB17876) (Green). Red: Negative Control. -
Gene Info — VAV1
Entrez GeneID
7409Protein Accession#
P15498Gene Name
VAV1
Gene Alias
VAV
Gene Description
vav 1 guanine nucleotide exchange factor
Omim ID
164875Gene Ontology
HyperlinkGene Summary
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq
Other Designations
oncogene vav|vav 1 oncogene|vav proto-oncogene
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Interactome
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Pathway
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