THRB monoclonal antibody, clone 2386
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of THRB.
Immunogen
A synthetic peptide corresponding to N-terminus human THRB.
Host
Mouse
Theoretical MW (kDa)
55
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of hippocampal lysate showing specific immunolabeling of the ~58k THRB protein. Using THRB monoclonal antibody, clone 2386 (Cat # MAB1784). -
Gene Info — THRB
Entrez GeneID
7068Protein Accession#
P10828Gene Name
THRB
Gene Alias
ERBA-BETA, ERBA2, GRTH, MGC126109, MGC126110, NR1A2, PRTH, THR1, THRB1, THRB2
Gene Description
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161044|avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2|oncogene ERBA2|thyroid hormone receptor beta 1|thyroid hormone receptor beta isoform|thyroid hormone receptor, beta
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Publication Reference
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Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain.
Constantinou C, Margarity M, Valcana T.
Molecular and Cellular Biochemistry 2005 Oct; 278(1-2):93.
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Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat.
Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G.
Neuroendocrinology 2005 Aug; 81(4):244.
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Thyroid hormone and central nervous system development.
Chan S, Kilby MD.
The Journal of Endocrinology 2000 Apr; 165(1):1.
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Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain.
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