ACVR1 monoclonal antibody, clone 2C1E8
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of (1) HEK293 cells, (2) ACVR1-hIgGFc transfected HEK293 cell lysate with ACVR1 monoclonal antibody.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of ACVR1 monoclonal antibody, clone 2C1E8.
Flow Cytometry
Flow cytometric analysis of HeLa cells with ACVR1 monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human ACVR1.
Immunogen
Recombinant protein corresponding to amino acids 21-120 of human ACVR1 from E. coli.
Host
Mouse
Theoretical MW (kDa)
72
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Immunocytochemistry
Immunohistochemistry
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of (1) HEK293 cells, (2) ACVR1-hIgGFc transfected HEK293 cell lysate with ACVR1 monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of ACVR1 monoclonal antibody, clone 2C1E8.Flow Cytometry
Flow cytometric analysis of HeLa cells with ACVR1 monoclonal antibody (green) and negative control (red). -
Gene Info — ACVR1
Entrez GeneID
90Gene Name
ACVR1
Gene Alias
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Gene Description
activin A receptor, type I
Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq
Other Designations
TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 2|activin A type I receptor|hydroxyalkyl-protein kinase|serine/threonine-protein kinase receptor R1
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Interactome
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Pathway
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Disease
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