THRA monoclonal antibody, clone 1718
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of hippocampal lysate showing specific immunolabeling of the ~50k THRA and the ~58k THRA isotype. Using THRA monoclonal antibody, clone 1718 (Cat # MAB1782).
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of THRA.
Immunogen
A synthetic peptide corresponding to N-terminus human THRA.
Host
Mouse
Theoretical MW (kDa)
50, 58
Reactivity
Dog, Human, Mouse, Rat
Specificity
Specific for the ~50k THRA and the ~58k TGFB1 proteins.
Form
Liquid
Purification
Protein G purification
Isotype
IgG2a
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of hippocampal lysate showing specific immunolabeling of the ~50k THRA and the ~58k THRA isotype. Using THRA monoclonal antibody, clone 1718 (Cat # MAB1782). -
Gene Info — THRA
Entrez GeneID
7067Protein Accession#
P10827Gene Name
THRA
Gene Alias
AR7, EAR7, ERB-T-1, ERBA, ERBA1, MGC000261, MGC43240, NR1A1, THRA1, THRA2, c-ERBA-1
Gene Description
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Omim ID
190120Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
ERBA-related 7|OTTHUMP00000164470|avian erythroblastic leukemia viral (v-erb-a) oncogene homolog|thyroid hormone receptor alpha|thyroid hormone receptor, alpha|triiodothyronine receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain.
Constantinou C, Margarity M, Valcana T.
Molecular and Cellular Biochemistry 2005 Oct; 278(1-2):93.
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Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat.
Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, Gerdoni E, Gallo G.
Neuroendocrinology 2005 Aug; 81(4):244.
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Thyroid hormone and central nervous system development.
Chan S, Kilby MD.
The Journal of Endocrinology 2000 Apr; 165(1):1.
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Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain.
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