PPM1A monoclonal antibody, clone 7F12
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of (1) Jurkat cell, (2) Jurkat cell, (3) A431 cell, (4) HeLa cell, (5) HEK293 cell, (6) Raji cell, (7) MCF-7 cell, (8) COS7 cell with PPM1A monoclonal antibody.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of PPM1A monoclonal antibody, clone 7F12.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human PPM1A.
Immunogen
Recombinant protein corresponding to amino acids 202-382 of human PPM1A from E. coli.
Host
Mouse
Theoretical MW (kDa)
42.4
Reactivity
Human, Monkey
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Immunocytochemistry
Immunohistochemistry
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of (1) Jurkat cell, (2) Jurkat cell, (3) A431 cell, (4) HeLa cell, (5) HEK293 cell, (6) Raji cell, (7) MCF-7 cell, (8) COS7 cell with PPM1A monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of PPM1A monoclonal antibody, clone 7F12. -
Gene Info — PPM1A
Entrez GeneID
5494Gene Name
PPM1A
Gene Alias
FLJ42306, MGC9201, PP2C-ALPHA, PP2CA
Gene Description
protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
Omim ID
606108Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
protein phosphatase 1A|protein phosphatase 2C alpha isoform
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Interactome
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Pathway
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Disease
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