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Last updated: 2017/10/22
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PRF1 monoclonal antibody, clone deltaG9

  • Catalog # : MAB1764
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native PRF1.
  • Immunogen:
  • Purified granules from human YT lymphoma cells
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 70
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes the 70 KDa perforin in human and primate.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • Immunoprecipitation
    Flow cytometry
    Immunohistochemistry (Frozen sections)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Immunocytochemistry
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl (0.5 mg/mL Gentamicin Sulfate).
  • Storage Instruction:
  • Store at 4°C.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 5551
  • Gene Name:
  • PRF1
  • Gene Alias:
  • FLH2,HPLH2,MGC65093,P1,PFN1,PFP
  • Gene Description:
  • perforin 1 (pore forming protein)
  • Gene Summary:
  • The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000019759,cytolysin,lymphocyte pore forming protein,perforin 1
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