KIR3DL1 monoclonal antibody, clone 6D9F6
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of (1) A431 cell, (2) Raji cell, (3) SPC-A-1 cell, (4) K562 cell, (5) HEK293 cell, (6) U937 cell, (7) C6 cell, (8) COS7 cell with KIR3DL1 monoclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded cervical cancer tissue with KIR3DL1 monoclonal antibody.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of KIR3DL1 monoclonal antibody, clone 6D9F6.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human KIR3DL1.
Immunogen
Recombinant protein corresponding to amino acid 22-340 of human KIR3DL1 from E. coli.
Host
Mouse
Theoretical MW (kDa)
49
Reactivity
Human, Monkey, Rat
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunocytochemistry
Flow Cytometry
Immunohistochemistry (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of (1) A431 cell, (2) Raji cell, (3) SPC-A-1 cell, (4) K562 cell, (5) HEK293 cell, (6) U937 cell, (7) C6 cell, (8) COS7 cell with KIR3DL1 monoclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded cervical cancer tissue with KIR3DL1 monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of KIR3DL1 monoclonal antibody, clone 6D9F6. -
Gene Info — KIR3DL1
Entrez GeneID
3811Gene Name
KIR3DL1
Gene Alias
CD158E1, KIR, MGC119726, MGC119728, MGC126589, MGC126591, NKAT3, NKB1, NKB1B
Gene Description
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
Gene Ontology
HyperlinkGene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
Other Designations
KIR antigen 3DL1|NK-receptor|killer cell immunoglobulin-like receptor 3DL1|natural killer-associated transcript 3|p70 killer cell inhibitory receptor
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Interactome
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Pathway
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Disease
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