GRM2 monoclonal antibody, clone 6E4F6
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of (1) SK-N-SH cell, (2) Jurkat cell, (3) SW620 cell with GRM2 monoclonal antibody.
Western Blot (Transfected lysate)
Western blot analysis of (1) HEK293 cells, (2) GRM2-hIgGFc transfected HEK293 cell lysate.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of GRM2 monoclonal antibody, clone 6E4F6.
Flow Cytometry
Flow cytometric analysis of SK-N-SH cells with GRM2 monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human GRM2.
Immunogen
Recombinant protein corresponding to amino acid 414-558 of human GRM2 from E. coli.
Host
Mouse
Theoretical MW (kDa)
95.6
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunocytochemistry
Flow Cytometry (1:200-1:400)
Immunohistochemistry
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of (1) SK-N-SH cell, (2) Jurkat cell, (3) SW620 cell with GRM2 monoclonal antibody.Western Blot (Transfected lysate)
Western blot analysis of (1) HEK293 cells, (2) GRM2-hIgGFc transfected HEK293 cell lysate.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of GRM2 monoclonal antibody, clone 6E4F6.Flow Cytometry
Flow cytometric analysis of SK-N-SH cells with GRM2 monoclonal antibody (green) and negative control (red). -
Gene Info — GRM2
Entrez GeneID
2912Gene Name
GRM2
Gene Alias
GLUR2, GPRC1B, MGLUR2, mGlu2
Gene Description
glutamate receptor, metabotropic 2
Omim ID
604099Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
glutamate metabotropic receptor 2|glutamate receptor homolog
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Interactome
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Pathway
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Disease
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