GRIA2 monoclonal antibody, clone 7A7D12
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of (1) HEK293 cells, (2) GRIA2-hIgGFc transfected HEK293 cell lysate.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of GRIA2 monoclonal antibody, clone 7A7D12.
Flow Cytometry
Flow cytometric analysis of SK-N-SH cells with GRIA2 monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human GRIA2.
Immunogen
Recombinant protein corresponding to amino acid 35-175 of human GRIA2 from E. coli.
Host
Mouse
Theoretical MW (kDa)
99
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunocytochemistry
Flow Cytometry (1:200-1:400)
Immunohistochemistry
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of (1) HEK293 cells, (2) GRIA2-hIgGFc transfected HEK293 cell lysate.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of GRIA2 monoclonal antibody, clone 7A7D12.Flow Cytometry
Flow cytometric analysis of SK-N-SH cells with GRIA2 monoclonal antibody (green) and negative control (red). -
Gene Info — GRIA2
Entrez GeneID
2891Gene Name
GRIA2
Gene Alias
GLUR2, GLURB, GluR-K2, HBGR2
Gene Description
glutamate receptor, ionotropic, AMPA 2
Omim ID
138247Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000165324|gluR-B|glutamate receptor 2
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Interactome
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Pathway
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Disease
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