OPRK1 monoclonal antibody, clone 5E3
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Specification
Product Description
Mouse monoclonal antibody raised against OPRK1.
Immunogen
hKOR expressing cell line.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Quality Control Testing
Antibody Reactive Against OPRK1.
Recommend Usage
Western Blot (5 ug/mL)
Immunoprecipitation (1 ug/mL)
Flow Cyt (1 ug/mL)
Immunoprecipitation (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Immunofluorescence analysis of HEK 293T cells overexpressing human OPRK1, using OPRK1 monoclonal antibody, clone 5E3 (Cat # MAB1740) .Immunoprecipitation
Flow Cytometry
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Gene Info — OPRK1
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Interactome
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Pathway
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Disease
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Publication Reference
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A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence.
Edenberg HJ, Wang J, Tian H, Pochareddy S, Xuei X, Wetherill L, Goate A, Hinrichs T, Kuperman S, Nurnberger JI Jr, Schuckit M, Tischfield JA, Foroud T.
Human Molecular Genetics 2008 Jun; 17(12):1783.
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Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.
Simonin F, Valverde O, Smadja C, Slowe S, Kitchen I, Dierich A, Le Meur M, Roques BP, Maldonado R, Kieffer BL.
The EMBO Journal 1998 Feb; 17(4):886.
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kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression.
Chao CC, Gekker G, Hu S, Sheng WS, Shark KB, Bu DF, Archer S, Bidlack JM, Peterson PK.
PNAS 1996 Jul; 93(15):8051.
Application:Flow Cyt, IF, Human, Microglial cells.
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kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
Simonin F, Gavériaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Mattéi MG, Charron G, Bloch B, Kieffer B.
PNAS 1995 Jul; 92(15):7006.
Application:IHC, WB-Ti, Human, Human brains.
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A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence.
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