HSPA5 monoclonal antibody, clone 1H11-1H7 (APC)
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More Files
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Immunocytochemistry
Immunocytochemical staining of HeLa cells with HSPA5 monoclonal antibody, clone 1H11-1H7 (APC) (Cat # MAB17319). (A) DAPI (blue) nuclear stain. (B) Anti-HSPA5 Antibody. (C) Composite.
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Specification
Product Description
Mouse monoclonal antibody raised against human HSPA5.
Immunogen
His-tagged human HSPA5.
Host
Mouse
Reactivity
Human
Form
Liquid
Conjugation
APC
Purification
Protein G purification
Isotype
IgG2b
Recommend Usage
Immunocytochemistry (1:100)
Immunofluorescence (1:100)
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide).
Storage Instruction
Store at -20°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunocytochemical staining of HeLa cells with HSPA5 monoclonal antibody, clone 1H11-1H7 (APC) (Cat # MAB17319). (A) DAPI (blue) nuclear stain. (B) Anti-HSPA5 Antibody. (C) Composite.Immunofluorescence
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Gene Info — HSPA5
Entrez GeneID
3309Protein Accession#
P11021Gene Name
HSPA5
Gene Alias
BIP, FLJ26106, GRP78, MIF2
Gene Description
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Omim ID
138120Gene Ontology
HyperlinkGene Summary
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM
Other Designations
Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD)|OTTHUMP00000022124|heat shock 70kD protein 5 (glucose-regulated protein, 78kD)|heat shock 70kDa protein 5
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Interactome
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Pathway
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Disease
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Publication Reference
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BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1.
Cho S, Park SM, Kim TD, Kim JH, Kim KT, Jang SK.
Molecular and Cellular Biology 2007 Jan; 27(1):368.
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BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1.
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