P2RX7 monoclonal antibody, clone 7G1D6
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: A431 cell; Lane 2: U251 cell; Lane 3: HeLa cell; Lane 4: U937 cell; Lane 5: HepG2 cell with P2RX7 monoclonal antibody.
Western Blot (Transfected lysate)
Western Blot analysis of (1) HEK293 cells, (2) P2RX7-hIgGFc transfected HEK293 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded esophageal cancer tissues with P2RX7 monoclonal antibody.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of P2RX7 monoclonal antibody, clone 7G1D6.
Flow Cytometry
Flow cytometric analysis of HeLa cells with P2RX7 monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human P2RX7.
Immunogen
Recombinant protein corresponding to amino acid 226-452 of human P2RX7 from E. coli.
Host
Mouse
Theoretical MW (kDa)
68.6kDa
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry (1:200-1:1000)
Immunocytochemistry
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: A431 cell; Lane 2: U251 cell; Lane 3: HeLa cell; Lane 4: U937 cell; Lane 5: HepG2 cell with P2RX7 monoclonal antibody.Western Blot (Transfected lysate)
Western Blot analysis of (1) HEK293 cells, (2) P2RX7-hIgGFc transfected HEK293 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of paraffin-embedded esophageal cancer tissues with P2RX7 monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of P2RX7 monoclonal antibody, clone 7G1D6.Flow Cytometry
Flow cytometric analysis of HeLa cells with P2RX7 monoclonal antibody (green) and negative control (red). -
Gene Info — P2RX7
Entrez GeneID
5027Gene Name
P2RX7
Gene Alias
MGC20089, P2X7
Gene Description
purinergic receptor P2X, ligand-gated ion channel, 7
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq
Other Designations
ATP receptor|P2X purinoceptor 7|P2X7 receptor|P2Z receptor|purinergic receptor P2X7
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Interactome
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Pathway
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Disease
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