SLC3A2 monoclonal antibody, clone WK4
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Specification
Product Description
Mouse monoclonal antibody raised against native SLC3A2.
Immunogen
Native purified from human cancer cel line.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG2a, kappa
Quality Control Testing
Antibody Reactive Against SLC3A2.
Recommend Usage
Flow Cyt (0.5-1 ug/mL)
Immunoprecipitation (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunoprecipitation
Flow Cytometry
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Gene Info — SLC3A2
Entrez GeneID
6520Gene Name
SLC3A2
Gene Alias
4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Gene Description
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
Omim ID
158070Gene Ontology
HyperlinkGene Summary
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
4F2 cell-surface antigen heavy chain|4F2 heavy chain|CD98 heavy chain|antigen defined by monoclonal antibody 4F2, heavy chain|antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43|heavy chain|lymphocyte activation antigen 4F2 large subu
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Interactome
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Disease
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Publication Reference
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Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells.
Gong S, Li Y, Su W, Ding Y, Lu J, Dong K, Hood S, Zhang W, Terstappen GC.
SLAS Discovery 2018 Mar; 2472555218761355.
Application：Func (endocytosis study), Human, Differentiated endothelial cells, hCMEC/D3 cells.
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CD98hc (SLC3A2) mediates integrin signaling.
Feral CC, Nishiya N, Fenczik CA, Stuhlmann H, Slepak M, Ginsberg MH.
PNAS 2005 Jan; 102(2):355.
Application：Flow Cyt, Mouse, Mouse embryonic stem cells.
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CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation.
Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, Ginsberg M, Sethi T.
The Journal of Biological Chemistry 2004 Dec; 279(52):54731.
Application：Flow Cyt, Mouse, CHO-K1 cells.
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Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation.
Nii T, Segawa H, Taketani Y, Tani Y, Ohkido M, Kishida S, Ito M, Endou H, Kanai Y, Takeda E, Miyamoto Ki.
The Biochemical Journal 2001 Sep; 358(Pt 3):693.
Application：IP, WB, Human, Jurkat cells.
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Distinct domains of CD98hc regulate integrins and amino acid transport.
Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C, Ginsberg MH.
The Journal of Biological Chemistry 2001 Mar; 276(12):8746.
Application：IP, Mouse, αβPy, CHO cells.
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4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.
Nakamura E, Sato M, Yang H, Miyagawa F, Harasaki M, Tomita K, Matsuoka S, Noma A, Iwai K, Minato N.
The Journal of Biological Chemistry 1999 Jan; 274(5):3009.
Application：IF, IHC, IP-WB, WB-Tr, Human, Mouse, COS, HeLa, P3U1 cells, Mouse brain, choroid plexus, intestine, kidney, retina, skin, thymus.
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Quantitative Algorithm-Based Paired Imaging Measurement for Antibody-Triggered Endocytosis in Cultured Cells.
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