DNMT3L monoclonal antibody, clone 2D10H11
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of (1) HEK293 cells, (2) DNMT3L-hIgGFc transfected HEK293 cell lysate.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of DNMT3L monoclonal antibody, clone 2D10H11.
Flow Cytometry
Flow cytometric analysis of HeLa cells with DNMT3L monoclonal antibody (green) and negative control (red).
-
Specification
Product Description
Mouse monoclonal antibody raised against recombinant human DNMT3L.
Immunogen
Recombinant protein corresponding to amino acid 147-386 of human DNMT3L from E. coli.
Host
Mouse
Theoretical MW (kDa)
43.6kDa
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry
Immunocytochemistry
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Transfected lysate)
Western Blot analysis of (1) HEK293 cells, (2) DNMT3L-hIgGFc transfected HEK293 cell lysate.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of DNMT3L monoclonal antibody, clone 2D10H11.Flow Cytometry
Flow cytometric analysis of HeLa cells with DNMT3L monoclonal antibody (green) and negative control (red). -
Gene Info — DNMT3L
Entrez GeneID
29947Gene Name
DNMT3L
Gene Alias
MGC1090
Gene Description
DNA (cytosine-5-)-methyltransferase 3-like
Omim ID
606588Gene Ontology
HyperlinkGene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined. [provided by RefSeq
Other Designations
cytosine-5-methyltransferase 3-like protein|human cytosine-5-methyltransferase 3-like protein
-
Interactome
-
Pathway
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com