MSR1 monoclonal antibody, clone SRA-C6
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More Files
- More Functions
Immunohistochemistry
Imunohistochemical analysis of human liver tissue, using MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) .
Immunohistochemistry
Imunohistochemical analysis of human alveolar macrophages, using MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) .
Inhibition Assay
Neutralizing activity of SRA-C6 (20 ug/mL) : Inhibitory effect of MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) on the degradation of ¹25;I-AcLDL by human monocyte-derived macrophages (day 7).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MSR1.
Immunogen
Recombinant protein corresponding to human MSR1.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Immunohistochemistry (5 ug/mL)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2.0% Block Ace)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Imunohistochemical analysis of human liver tissue, using MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) .Immunohistochemistry
Imunohistochemical analysis of human alveolar macrophages, using MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) .Inhibition Assay
Neutralizing activity of SRA-C6 (20 ug/mL) : Inhibitory effect of MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) on the degradation of ¹25;I-AcLDL by human monocyte-derived macrophages (day 7). -
Gene Info — MSR1
Entrez GeneID
4481Gene Name
MSR1
Gene Alias
CD204, SCARA1, SR-A, phSR1, phSR2
Gene Description
macrophage scavenger receptor 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq
Other Designations
OTTHUMP00000120049|OTTHUMP00000120050|macrophage acetylated LDL receptor I and II|macrophage scavenger receptor type III|scavenger receptor class A, member 1
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Interactome
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Disease
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Publication Reference
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Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes.
Fukuhara-Takaki K, Sakai M, Sakamoto Y, Takeya M, Horiuchi S.
The Journal of Biological Chemistry 2005 Feb; 280(5):3355.
Application：WB-Ce, Human, Mouse, Monocyte-derived macrophages.
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Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors.
Tomokiyo R, Jinnouchi K, Honda M, Wada Y, Hanada N, Hiraoka T, Suzuki H, Kodama T, Takahashi K, Takeya M.
Atherosclerosis 2002 Mar; 161(1):123.
Application：IHC-Fr, WB, Human, Mouse, Alveolar macrophages, Human cells and tissues, J774A.1, Monocytes, Raw264.7, THP-1 cells.
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Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes.
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