Imunohistochemical analysis of human alveolar macrophages, using MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) .
Imunohistochemical analysis of human liver tissue, using MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) .
Neutralizing activity of SRA-C6 (20 ug/mL) : Inhibitory effect of MSR1 monoclonal antibody, clone SRA-C6 (Cat # MAB1716) on the degradation of ¹25;I-AcLDL by human monocyte-derived macrophages (day 7).
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq
OTTHUMP00000120049,OTTHUMP00000120050,macrophage acetylated LDL receptor I and II,macrophage scavenger receptor type III,scavenger receptor class A, member 1