MSR1 monoclonal antibody, clone SRA-E5
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of lysate of THP-1 cells, a human histiocytic cell line. A single band at 72 kD is observed. DTT treated.
Immunohistochemistry
Imunohistochemical analysis of Human liver (paraffin section) Kupffer cells are positively stained.
Immunohistochemistry
Imunohistochemical analysis of Skin Sarcoidosis (paraffin section) Epithelioid cells and multi-nucleated giant cells in granulomas and surrounding macrophages are positive.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MSR1.
Immunogen
Recombinant protein corresponding to human MSR1.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein G affinity chromatography
Isotype
IgG1
Recommend Usage
Immunohistochemistry (10 ug/mL) (Antigen retrieval (microwave 10 min , 0.01 M citrate buffer, pH 2.0) is recommended for paraffin sections.)
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer (0.1% Proclin, Block Ace).
Storage Instruction
Store at -20°C or below.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of lysate of THP-1 cells, a human histiocytic cell line. A single band at 72 kD is observed. DTT treated.Immunohistochemistry
Imunohistochemical analysis of Human liver (paraffin section) Kupffer cells are positively stained.Immunohistochemistry
Imunohistochemical analysis of Skin Sarcoidosis (paraffin section) Epithelioid cells and multi-nucleated giant cells in granulomas and surrounding macrophages are positive. -
Gene Info — MSR1
Entrez GeneID
4481Gene Name
MSR1
Gene Alias
CD204, SCARA1, SR-A, phSR1, phSR2
Gene Description
macrophage scavenger receptor 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq
Other Designations
OTTHUMP00000120049|OTTHUMP00000120050|macrophage acetylated LDL receptor I and II|macrophage scavenger receptor type III|scavenger receptor class A, member 1
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Interactome
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Disease
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Publication Reference
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Clinicopathologic profiles of canine ocular melanosis: A comparative study between cairn terriers and non-cairn terriers.
J Seth Eaton, Sanskruti S Potnis, Alexis Cavanaugh, Cody A Davis, Leandro B C Teixeira, Gillian C Shaw.
Veterinary Ophthalmology 2024 Feb; [Epub].
Application：IHC, Dog, Dog globes.
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CYP19A1 mediates severe SARS-CoV-2 disease outcome in males.
Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Kouassi Mounogou, Berfin Schaumburg, Fabian Stoll, Amirah Al Jawazneh, Zoé Schmal, Tian Bai, Martin Zickler, Georg Beythien, Kathrin Becker, Madeleine de la Roi, Fabian Heinrich, Claudia Schulz, Martina Sauter, Susanne Krasemann, Philine Lange, Axel Heinemann, Debby van Riel, Lonneke Leijten, Lisa Bauer, Thierry P P van den Bosch, Boaz Lopuhaä, Tobias Busche, Daniel Wibberg, Dirk Schaudien, Torsten Goldmann, Anna Lüttjohann, Jenny Ruschinski, Han
Cell Reports. Medicine 2023 Sep; 4(9):101152.
Application：IHC, Human, Lung tissue.
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Tumor-associated macrophages in canine visceral hemangiosarcoma.
Mikael Kerboeuf, Didrik Andreas Haugeberg, Tobias Olsen, Linn Kaia Sørling, Erling Olaf Koppang, Lars Moe, Anita Haug Haaland.
Veterinary Pathology 2023 Jun; 3009858231179940:0.
Application：IHC-P, Dog, Dog heart, Dog liver, Dog lung, Dog spleen.
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Vascular Inflammation Is Associated with Loss of Aquaporin 1 Expression on Endothelial Cells and Increased Fluid Leakage in SARS-CoV-2 Infected Golden Syrian Hamsters.
Lisa Allnoch, Georg Beythien, Eva Leitzen, Kathrin Becker, Franz-Josef Kaup, Stephanie Stanelle-Bertram, Berfin Schaumburg, Nancy Mounogou Kouassi, Sebastian Beck, Martin Zickler, Vanessa Herder, Gülsah Gabriel, Wolfgang Baumgärtner.
Viruses 2021 Apr; 13(4):639.
Application：IHC-P, Hamster, Hamster Lung.
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Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth.
Ruo-Yu Ma, Hui Zhang, Xue-Feng Li, Cheng-Bin Zhang, Cigdem Selli, Giulia Tagliavini, Alyson D Lam, Sandrine Prost, Andrew H Sims, Hai-Yan Hu, Tianlei Ying, Zhan Wang, Zhaoming Ye, Jeffrey W Pollard, Bin-Zhi Qian.
The Journal of Experimental Medicine 2020 Nov; 217(11):e20191820.
Application：Flow Cyt, IF, IHC-P, Human, Mouse, Human breast cancer, Human macrophages, Met-1 cells, Mouse macrophages, Mouse monocytes.
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Plasma cell leukemia with plasmablastic morphology in a dog.
Dagher E, Soetart N, Chocteau F, Dequéant B, Piccirillo E, Ibisch C, Abadie J, Jaillardon L.
Journal of Veterinary Diagnostic Investigation 2019 Nov; 31(6):868.
Application：IHC-P, Human, Disseminated plasma cell leukemia with plasmablastic morphology.
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Immune-phenotyping of pleomorphic dermal sarcomas suggests this entity as a potential candidate for immunotherapy.
Klein S, Mauch C, Wagener-Ryczek S, Schoemmel M, Buettner R, Quaas A, Helbig D.
Cancer Immunology, Immunotherapy : CII 2019 Jun; 68(6):973.
Application：IHC-P, Human, Human pleomorphic dermal sarcomas.
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Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors.
Tomokiyo R, Jinnouchi K, Honda M, Wada Y, Hanada N, Hiraoka T, Suzuki H, Kodama T, Takahashi K, Takeya M.
Atherosclerosis 2002 Mar; 161(1):123.
Application：IHC-Fr, WB, Human, Mouse, Alveolar macrophages, Human cells and tissues, J774A.1, Monocytes, Raw264.7, THP-1 cells.
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Clinicopathologic profiles of canine ocular melanosis: A comparative study between cairn terriers and non-cairn terriers.
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