Product Browser

Last updated: 2016/12/4
  • Related Product Showcase

Product Compare

Product Compare Cancel Click this icon to add products to compare list. Select up to 10 products.

Quick Order (Tutorial)

Input Catalog #,
place order here!
Catalog # :
  • Where to buy
  • Choose your location

MSR1 monoclonal antibody, clone SRA-E5

  • Catalog # : MAB1710
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant MSR1.
  • Immunogen:
  • Recombinant protein corresponding to human MSR1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Immunohistochemistry (10 ug/mL)
    Western Blot (2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.1% proclin, 2.0% Block Ace)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of extract from THP-1 cells, using MSR1 monoclonal antibody, clone SRA-E5 (Cat # MAB1710) .
  • Immunohistochemistry
  • Immunohistochemistry
  • Imunohistochemical analysis of human skin tissue, using MSR1 monoclonal antibody, clone SRA-E5 (Cat # MAB1710) .
  • Immunohistochemistry
  • Immunohistochemistry
  • Imunohistochemical analysis of human liver tissue, using MSR1 monoclonal antibody, clone SRA-E5 (Cat # MAB1710) .
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4481
  • Gene Name:
  • MSR1
  • Gene Alias:
  • CD204,SCARA1,SR-A,phSR1,phSR2
  • Gene Description:
  • macrophage scavenger receptor 1
  • Gene Summary:
  • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000120049,OTTHUMP00000120050,macrophage acetylated LDL receptor I and II,macrophage scavenger receptor type III,scavenger receptor class A, member 1
  • RSS
  • YouTube
  • Linkedin
  • Facebook