ANK2 monoclonal antibody, clone S105-13 (APC)
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More Files
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Immunocytochemistry
Immunocytochemical staining of SK-N-BE with ANK2 monoclonal antibody, clone S105-13 (APC) (Cat # MAB16996). (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ANK2 Antibody and (D) Composite.
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of human ANK2.
Immunogen
A synthetic peptide corresponding to amino acids 203-496 of human ANK2.
Host
Mouse
Reactivity
Human
Form
Liquid
Conjugation
APC
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Immunocytochemistry (1:200)
Immunofluorescence (1:200)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide).
Storage Instruction
Store at -20°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
Immunocytochemical staining of SK-N-BE with ANK2 monoclonal antibody, clone S105-13 (APC) (Cat # MAB16996). (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) ANK2 Antibody and (D) Composite.Immunofluorescence
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Gene Info — ANK2
Entrez GeneID
287Protein Accession#
Q01484Gene Name
ANK2
Gene Alias
DKFZp686M09125, DKFZp686P0948, FLJ38277, LQT4
Gene Description
ankyrin 2, neuronal
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000163834|ankyrin 2|ankyrin B|ankyrin, brain|ankyrin, nonerythroid|ankyrin-2, nonerythrocytic|brank-2
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Interactome
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Disease
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Publication Reference
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Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.
Bennett V, Baines AJ.
Physiological Reviews 2001 Jul; 81(3):1353.
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Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.
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