CSF2RA monoclonal antibody, clone 4H1
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis (surface staining) of human peripheral blood with anti-CSF2RA PE.
Mass Cytometry
Mass cytometry analysis (surface staining) of human peripheral blood with anti-CSF2RA 153Eu. Gated on singlets.
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Specification
Product Description
Mouse monoclonal antibody raised against human CSF2RA.
Immunogen
CSF2RA-transfected COS cells.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes human CD116, the GM-CSF receptor alpha subunit (approxmately 80 kDa) expressed by neutrophils, eosinophils, monocytes and macrophages.
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Flow Cytometry
Immunoprecipitation
Immunohistochemistry (Frozen sections)
Mass Cytometry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 8.0 (15 mM sodium azide).
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis (surface staining) of human peripheral blood with anti-CSF2RA PE.Mass Cytometry
Mass cytometry analysis (surface staining) of human peripheral blood with anti-CSF2RA 153Eu. Gated on singlets. -
Gene Info — CSF2RA
Entrez GeneID
1438Gene Name
CSF2RA
Gene Alias
CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, MGC3848, MGC4838
Gene Description
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq
Other Designations
CD116 antigen|GM-CSF receptor alpha subunit|OTTHUMP00000014504|OTTHUMP00000014505|OTTHUMP00000014917|OTTHUMP00000014918|colony stimulating factor 2 receptor alpha chain|colony stimulating factor 2 receptor alpha subunit|granulocyte-macrophage colony-stimu
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Interactome
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Pathway
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Disease
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Publication Reference
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Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-β against peritoneally disseminated cancer in xenograft models.
Chihiro Koba, Miwa Haruta, Yusuke Matsunaga, Keiko Matsumura, Eriko Haga, Yuko Sasaki, Tokunori Ikeda, Koutaro Takamatsu, Yasuharu Nishimura, and Satoru Senju.
PLoS One 2013 Jun; 8(6):e67567.
Application：Flow Cyt, Human, Human induced pluripotent stem cells.
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Peripheral monocyte functions and activation in patients with quiescent Crohn's disease.
David Schwarzmaier, Dirk Foell, Toni Weinhage, Georg Varga, and Jan Dabritz.
PLoS One 2013 Apr; 8(4):e62761.
Application：Flow Cyt, Human, Human monocytes.
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IL-15 trans-presentation promotes human NK cell development and differentiation in vivo.
Nicholas D. Huntington, Nicolas Legrand, Nuno L. Alves, Barbara Jaron, Kees Weijer, Ariane Plet, Erwan Corcuff, Erwan Mortier, Yannick Jacques, Hergen Spits, and James P. Di Santo.
The Journal of Experimental Medicine 2009 Jan; 206(1):25.
Application：Flow Cyt, Human, Human myeloid cells, Human nature killer cells.
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Therapeutic effect of human iPS-cell-derived myeloid cells expressing IFN-β against peritoneally disseminated cancer in xenograft models.
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