GRIA1 (phospho S845) monoclonal antibody, clone RM296
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot (Tissue lysate) analysis of mouse brain (1) non-treated with Lambda Protein Phosphatase (λPP), (2) dephosphorylated with Lambda Protein Phosphatase (λPP).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human GRIA1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic phosphopeptide corresponding to residues surrounding Ser845 of human GRIA1.
Reactivity
Human, Mouse, Rat
Specificity
This antibody reacts to human Glutamate Receptor 1, AMPA Receptor (GluR1) only when phosphorylated at Ser845. There is no cross-reactivity to GluR1 that is not phosphorylated at Ser845. This antibody may also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1000)
Western Blot (1:1000-2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot (Tissue lysate) analysis of mouse brain (1) non-treated with Lambda Protein Phosphatase (λPP), (2) dephosphorylated with Lambda Protein Phosphatase (λPP).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain. -
Gene Info — GRIA1
Entrez GeneID
2890Gene Name
GRIA1
Gene Alias
GLUH1, GLUR1, GLURA, HBGR1, MGC133252
Gene Description
glutamate receptor, ionotropic, AMPA 1
Omim ID
138248Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AMPA 1
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Interactome
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Pathway
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Disease
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