GAD2 monoclonal antibody, clone 5D9G12
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human GAD2.
Immunogen
Recombinant protein corresponding to amino acid 1-100 of human GAD2 from E. coli.
Host
Mouse
Theoretical MW (kDa)
65.4
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry
Immunocytochemistry
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: HEK293 cell; Lane 2: GAD2-hIgGFc transfected HEK293 cell with GAD2 monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of GAD2 monoclonal antibody, clone 5D9G12.Flow Cytometry
Flow cytometric analysis of Hela cells with GAD2 monoclonal antibody (green) and negative control (red). -
Gene Info — GAD2
Entrez GeneID
2572Gene Name
GAD2
Gene Alias
GAD65, MGC161605, MGC161607
Gene Description
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Omim ID
138275Gene Ontology
HyperlinkGene Summary
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq
Other Designations
Glutamate decarboxylase-2 (pancreas)|OTTHUMP00000019335|OTTHUMP00000019336|glutamate decarboxylase 2|glutamate decarboxylase 2 (pancreatic islets and brain, 65kD)
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