LDLR monoclonal antibody, clone 7H5B11
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: HEK293 cell; Lane 2: LDLR-hIgGFc transfected HEK293 cell with LDLR monoclonal antibody.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of LDLR monoclonal antibody, clone 7H5B11.
Flow Cytometry
Flow cytometric analysis of Hela cells with LDLR monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human LDLR.
Immunogen
Recombinant protein corresponding to amino acid 22-150 of human LDLR from E. coli.
Host
Mouse
Theoretical MW (kDa)
95.4
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry
Immunocytochemistry
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: HEK293 cell; Lane 2: LDLR-hIgGFc transfected HEK293 cell with LDLR monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of LDLR monoclonal antibody, clone 7H5B11.Flow Cytometry
Flow cytometric analysis of Hela cells with LDLR monoclonal antibody (green) and negative control (red). -
Gene Info — LDLR
Entrez GeneID
3949Gene Name
LDLR
Gene Alias
FH, FHC
Gene Description
low density lipoprotein receptor
Gene Ontology
HyperlinkGene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
Other Designations
LDL receptor|low-density lipoprotein receptor class A domain-containing protein 3
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Interactome
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Pathway
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Disease
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