CASP3 monoclonal antibody, clone 3D4D10
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Hela cell; Lane 2: Jurkat cell; Lane 3: HepG2 cell; Lane 4: BCL-1 cell; Lane 5: C6 cell; Lane 6: SK-Br-3 cell; Lane 7: NIH/3T3 cell and Lane 8: A549 cell with CASP3 monoclonal antibody.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of CASP3 monoclonal antibody, clone 3D4D10.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human CASP3.
Immunogen
Recombinant protein corresponding to amino acid 29-175 of human CASP3 from E. coli.
Host
Mouse
Theoretical MW (kDa)
31.6
Reactivity
Human, Mouse, Rat
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Immunohistochemistry
Immunocytochemistry
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Hela cell; Lane 2: Jurkat cell; Lane 3: HepG2 cell; Lane 4: BCL-1 cell; Lane 5: C6 cell; Lane 6: SK-Br-3 cell; Lane 7: NIH/3T3 cell and Lane 8: A549 cell with CASP3 monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of CASP3 monoclonal antibody, clone 3D4D10. -
Gene Info — CASP3
Entrez GeneID
836Gene Name
CASP3
Gene Alias
CPP32, CPP32B, SCA-1
Gene Description
caspase 3, apoptosis-related cysteine peptidase
Omim ID
600636Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000165054|PARP cleavage protease|SREBP cleavage activity 1|Yama|apopain|caspase 3|caspase 3, apoptosis-related cysteine protease|cysteine protease CPP32|procaspase3
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Interactome
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Pathway
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Disease
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