APP monoclonal antibody, clone 5H10A10
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: HEK293 cell; Lane 2: APP-hIgGFc transfected HEK293 cell with APP monoclonal antibody.
Enzyme-linked Immunoabsorbent Assay
ELISA analysis of APP monoclonal antibody, clone 5H10A10.
Flow Cytometry
Flow cytometric analysis of Hela cells with APP monoclonal antibody (green) and negative control (red).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human APP.
Immunogen
Recombinant protein corresponding to amino acid 483-699 of human APP from E. coli.
Host
Mouse
Theoretical MW (kDa)
87
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
Flow Cytometry (1:200-1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of Lane 1: HEK293 cell; Lane 2: APP-hIgGFc transfected HEK293 cell with APP monoclonal antibody.Enzyme-linked Immunoabsorbent Assay
ELISA analysis of APP monoclonal antibody, clone 5H10A10.Flow Cytometry
Flow cytometric analysis of Hela cells with APP monoclonal antibody (green) and negative control (red). -
Gene Info — APP
Entrez GeneID
351Gene Name
APP
Gene Alias
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gene Description
amyloid beta (A4) precursor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II
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Interactome
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Disease
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