Formalin-fixed and paraffin-embedded human neurofibroma tissue (A; 4 um), skin melanoma tissue (B; 4 um), and human breast tissue (C; 4 um) stained with S100A1 monoclonal antibody, clone D28-E (Cat # MAB1659) show: A - positive immunostaining of tumor cells and peripheral nerve; B - strong positive immunostaining of melanoma cells; C - strong positive immunostaining of the outer myoepithelial cell component in mammary lobule. Kindly performed and provided by Katarina Poliakova, MD and Lubomir Straka, MD, Ph. D., from Clinical Pathology Presov, Ltd., Presov, Slovakia.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq
OTTHUMP00000035100,S100 alpha,S100 calcium-binding protein A1,S100 protein, alpha polypeptide