NLRP6 monoclonal antibody, clone Clint-1
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human NLRP6.
Immunogen
Recombinant protein corresponding to NACHT domain of human NLRP6.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
>95% (SDS-PAGE)
Isotype
IgG1, kappa
Recommend Usage
Immunohistochemistry (Frozen sections) (1:500)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (10% glycerol, 0.02% sodium azide).
Storage Instruction
For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
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Gene Info — NLRP6
Entrez GeneID
171389Protein Accession#
P59044Gene Name
NLRP6
Gene Alias
CLR11.4, NALP6, PAN3, PYPAF5
Gene Description
NLR family, pyrin domain containing 6
Omim ID
609650Gene Ontology
HyperlinkGene Summary
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
Other Designations
NACHT, LRR and PYD containing protein 6|NACHT, leucine rich repeat and PYD containing 6|OTTHUMP00000147611|PYRIN-containing APAF1-like protein 5|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6
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Interactome
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Disease
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