VISA monoclonal antibody, clone Adri-1
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human VISA.
Immunogen
Recombinant protein corresponding to amino acids 160-450 of human VISA.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
>95% (SDS-PAGE)
Isotype
IgG2b
Recommend Usage
Immunocytochemistry (1:100)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoprecipitation (1:200)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (10% glycerol, 0.02% sodium azide).
Storage Instruction
For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
Immunoprecipitation
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Gene Info — VISA
Entrez GeneID
57506Protein Accession#
Q7Z434Gene Name
VISA
Gene Alias
CARDIF, DKFZp547C224, DKFZp666M015, FLJ27482, FLJ35386, FLJ38051, FLJ41962, IPS-1, IPS1, KIAA1271, MAVS, MGC3260
Gene Description
virus-induced signaling adapter
Omim ID
609676Gene Ontology
HyperlinkGene Summary
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM
Other Designations
CARD adapter inducing interferon-beta|OTTHUMP00000030141|interferon-beta promoter stimulator protein 1|mitochondrial anti-viral signaling protein|virus-induced signaling adapter variant 1b|virus-induced signaling adaptor variant 1a
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Interactome
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Disease
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