FGF23 monoclonal antibody, clone FG322-3
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human FGF23.
Immunogen
Recombinant protein corresponding to human FGF23.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
ELISA (1:2000-5000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-500)
Western Blot (1:2000-5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4.
Storage Instruction
For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — FGF23
Entrez GeneID
8074Protein Accession#
Q9GZV9Gene Name
FGF23
Gene Alias
ADHR, HPDR2, HYPF, PHPTC
Gene Description
fibroblast growth factor 23
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia. [provided by RefSeq
Other Designations
tumor-derived hypophosphatemia inducing factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Clinical, morphological and immunohistochemical analysis of 13 cases of phosphaturic mesenchymal tumor - A holistic diagnostic approach.
Debajyoti Chatterjee, Anand Bardia, Rimesh Pal, Uma Nahar Saikia, Sanjay Kumar Bhadada, Bishan Dass Radotra.
Annals of Diagnostic Pathology 2021 Oct; 54:151783.
Application:IHC-P, Human, Human phosphaturic mesenchymal tumor.
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Clinical, morphological and immunohistochemical analysis of 13 cases of phosphaturic mesenchymal tumor - A holistic diagnostic approach.
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