PGR monoclonal antibody, clone A21-W
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human PGR.
Immunogen
A synthetic peptide corresponding to N-terminus of human PGR.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
EVAC purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl buffer, pH 8.0 (20 mg/mL BSA, 0.05% Sodium Azide).
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with PGR monoclonal antibody, clone A21-W (Cat # MAB15968). -
Gene Info — PGR
Entrez GeneID
5241Protein Accession#
P06401Gene Name
PGR
Gene Alias
NR3C3, PR
Gene Description
progesterone receptor
Omim ID
607311Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.
Kunasegaran K, Ho V, Chang TH, De Silva D, Bakker ML, Christoffels VM, Pietersen AM.
PloS One 2014 Oct; 9(10):e110191.
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Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.
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