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NR0B2 monoclonal antibody, clone SH2G5-C

  • Catalog # : MAB15874
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against human NR0B2.
  • Immunogen:
  • Recombinant protein corresponding to human NR0B2.
  • Host:
  • Rat
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • ELISA (1:5000-1:10000)
    Western Blot (1:2000-1:10000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4.
  • Storage Instruction:
  • For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • ELISA
  • Application Image
  • Western Blot
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8431
  • Gene Name:
  • NR0B2
  • Gene Alias:
  • FLJ17090,SHP,SHP1
  • Gene Description:
  • nuclear receptor subfamily 0, group B, member 2
  • Gene Summary:
  • The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000004414,orphan nuclear receptor SHP,short heterodimer partner,small heterodimer partner
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