Products

Western Blot (Transfected lysate)

Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with ARID1A monoclonal antibody, clone CL3595 (Cat # MAB15809).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with ARID1A monoclonal antibody, clone CL3595 (Cat # MAB15809) shows moderate to strong nuclear immunoreactivity in tumor cells.

Entrez GeneID

8289

Protein Accession#

O14497

Gene Name

ARID1A

Gene Alias

B120, BAF250, BAF250a, BM029, C1orf4, P270, SMARCF1

Gene Description

AT rich interactive domain 1A (SWI-like)

Omim ID

603024

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

AT rich interactive domain 1A|AT rich interactive domain 1A (SWI- like)|BRG1-associated factor 250a|OSA1 nuclear protein|OTTHUMP00000004117|OTTHUMP00000044975|SWI/SNF complex protein p270|SWI/SNF related, matrix associated, actin dependent regulator of ch