LAMA2 monoclonal antibody, clone CL3450
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More Files
- More Functions
Western Blot (Recombinant protein)
Western Blot analysis of recombinant protein Lane 1: Laminin-211, Lane 2: Laminin-221, Lane 3: Laminin-332, Lane 4: Laminin-421, Lane 5: Laminin-511 and Lane 6: Laminin-121 with LAMA2 monoclonal antibody, clone CL3450 (Cat # MAB15802).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human heart muscle with LAMA2 monoclonal antibody, clone CL3450 (Cat # MAB15802) shows membranous immunoreactivity in muscle fibers.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human LAMA2.
Immunogen
Recombinant protein corresponding to human LAMA2.
Epitope
This antibody binds to an epitope located within the peptide sequence DKLKPIKELEDNLKK as determined by overlapping synthetic peptides.
Sequence
DKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGT
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western Blot analysis of recombinant protein Lane 1: Laminin-211, Lane 2: Laminin-221, Lane 3: Laminin-332, Lane 4: Laminin-421, Lane 5: Laminin-511 and Lane 6: Laminin-121 with LAMA2 monoclonal antibody, clone CL3450 (Cat # MAB15802).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human heart muscle with LAMA2 monoclonal antibody, clone CL3450 (Cat # MAB15802) shows membranous immunoreactivity in muscle fibers. -
Gene Info — LAMA2
Entrez GeneID
3908Protein Accession#
P24043Gene Name
LAMA2
Gene Alias
LAMM
Gene Description
laminin, alpha 2
Gene Ontology
HyperlinkGene Summary
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000017189|laminin M|laminin alpha 2 subunit|merosin heavy chain
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Interactome
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Pathway
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Disease
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