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SLC6A3 monoclonal antibody, clone CL3123

  • Catalog # : MAB15791
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant human SLC6A3.
  • Immunogen:
  • Recombinant protein corresponding to human SLC6A3.
  • Sequence:
  • LHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLG
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Epitope:
  • This antibody binds to an epitope located within the peptide sequence ELPWIHCNNSWNSPN as determined by overlapping synthetic peptides.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human substantia nigra with SLC6A3 monoclonal antibody, clone CL3123 (Cat # MAB15791) shows moderate immunoreactivity in dopamine neurons and fibers.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Entrez GeneID:
  • 6531
  • Gene Name:
  • SLC6A3
  • Gene Alias:
  • DAT,DAT1
  • Gene Description:
  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  • Gene Summary:
  • The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission. The DAT1 gene has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse (Vandenbergh et al., 1992 [PubMed 1359373]).[supplied by OMIM
  • Other Designations:
  • dopamine transporter,variable number tandem repeat (VNTR)
  • Gene Pathway
  • Related Disease
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